This is the bit that nobody wants to know about.

Prolonged high oral doses of hormones can have a damaging effect on the liver. It’s important to have regular blood tests to ensure proper liver function.

Oestrogens tend to make blood vessels slightly softer, reducing the chance of heart attacks. However, there is an increased chance of blood clots, varicose veins, and stroke.

Testosterone tends to increase the risk of arterial hardening, leading to a correspondingly increased risk of heart attack.